![]() ![]() ![]() Mutants were also subjected to clinical observation and visual function evaluation with the optomotor test and electroretinography.īoth isoform transcripts of RARα were expressed throughout the neural retina at various stages of pre- and postnatal development. Immunofluorescence was used to detect differentiated cell types in the adult retina. In situ hybridization was performed on serial eye sections to investigate the expression of main developmental regulators. An RA-response element (RARE)–containing reporter transgene was used to assess the contribution of RARα to retinoid signaling in the retina. RARα mutant ( Rara −/−) mice were compared with wild-type littermates at several stages of pre- and postnatal development. To determine the functional contribution of retinoic acid receptor (RAR)-α in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. ![]()
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